Roadshow
DuloCore® Ⅱ resin
Tantti Lab has developed a novel, giga-porous resin, DuloCore® for biopharmaceutical production. It combines the advantages of both traditional packed beads and monolithic columns, which not only provides higher binding capacity and recovery rate for larger biomolecules but also applies convection flow mode to achieve the advantages of high throughput, high flow rate, and low back-pressure in downstream purification. In addition, both resin size and pore size are tunable in this patented DuloCore® technology and can apply to the broad spectrum of biologic drugs from proteins, AAVs, plasmid DNA, mRNA, lentivirus to large extracellular vehicles (EVs/Exosomes). The developed DuloCore® technology not only can accelerate the development and production of biopharmaceuticals but also make these new biologic drugs more affordable to the clinical patients.
Recently, there has been a paradigm shift in the therapies of cancers and immune diseases using biopharmaceuticals. However, the availabilities of these biologic drugs to the clinical patients are still limited due to their high prices. Many technologies have been developed to optimize and reduce the cost of the bioprocessing. However, down stream purification using traditional chromatographic resins, e.g. agarose or polystyrene, remains limited efficiency and becomes the major cost in the biologic drug production.
DuloCore DEAE column has proven its capability in removing the impurities from the cell lysate and isolating the desired DNA plasmids. The gel electrophoresis results support high purity of the DNA fractions has been collected
Separation of Empty and Full AAV8 Capsids
Purifications of Plasmid DNA
- Established 2014
- Company Tantti Laboratory Inc.
- Telephone +886-3-346 7989
- Address 5F., No. 50, Minquan Rd., Luzhu Dist., Taoyuan City, Taiwan
Tantti Lab founded in 2014 has developed the porous biomaterial platform technologies and focuses on biotechnology applications. The current flagship products are dissolvable microcarriers for high density cell expansion and high capacity chromatography resins for high throughput bioseparations. Their application targets include stem cells, CAR-T cells, protein drugs, viral vectors, vaccine, DNA, mRNA, exosomes, etc. These innovated products with unique porous structures provide high-efficient performance and address the unmet needs in biopharmaceutical R&D and production which greatly reduce the production costs of the target biologics. Such innovated technologies and products have gained great attention from the global bioprocessing suppliers and initiate the partnership discussion. Tantti has positioned itself as the supplier of innovated materials used in biopharma and becomes the new star in Taiwan biopharma manufacturing.